4 maart — Internationale HPV Awareness Day

Via onderstaand overzicht vind je deze publicaties gebundeld. Zo maken we zichtbaar hoe data uit de dagelijkse pathologiepraktijk bijdraagt aan preventie, vroegtijdige opsporing en betere zorg:

1. Goetgebuer RL, Kreijne JE, Aitken CA, et al. Increased Risk of High-grade Cervical Neoplasia in Women with Inflammatory Bowel Disease: A Case-controlled Cohort Study. J Crohns Colitis. 2021;15:1464–73. doi: 10.1093/ecco-jcc/jjab036

2. Bas S, Sijben J, Bischoff EWMA, et al. Acceptability of risk-based triage in cervical cancer screening: A focus group study. PLoS One. 2023;18. doi: 10.1371/journal.pone.0289647

3. Loopik DL, Koenjer LM, Siebers AG, et al. Benefit and burden in the Dutch cytology-based vs high-risk human papillomavirus-based cervical cancer screening program. Am J Obstet Gynecol. 2021;224:200.e1-200.e9. doi: 10.1016/j.ajog.2020.08.026

4. Inturrisi F, Aitken CA, Melchers WJG, et al. Clinical performance of high-risk HPV testing on self-samples versus clinician samples in routine primary HPV screening in the Netherlands: An observational study. The Lancet Regional Health - Europe. 2021;11. doi: 10.1016/j.lanepe.2021.100235

5. Schevenhoven VJC, Jansen EEL, Siebers AG, et al. Long-Term Cervical Cancer Risk Following Negative hrHPV-based Versus Negative Cytology-based Screening: A Population-based Study. Eur J Cancer. 2026;116601. doi: 10.1016/j.ejca.2026.116601

6. de Waard J, Bhattacharya A, de Boer MT, et al. Clinical validation of a three-marker methylation panel to detect CIN3+ in vaginal self-samples in the Dutch population-based screening programme. Clin Epigenetics. Published Online First: 23 November 2025. doi: 10.1186/S13148-025-02020-W

7. Olthof EMG, van den Brule AJC, Melchers WJG, et al. Improving Efficiency in Dutch Cervical Screening by Genotyping: An Analysis of Real World Program Data. J Med Virol. 2025;97. doi: 10.1002/JMV.70745

8. Middeldorp M, Brouwer JGM, Duijster JW, et al. The effect of bivalent HPV vaccination against invasive cervical cancer and CIN3+ in the Netherlands: a national linkage study. medRxiv. Published Online First: 28 February 2025. doi: 10.1101/2025.02.27.25322519

9. Ebisch RMF, Buijssen C, Visser NCM, et al. The Risk of Developing Cervical Cancer in the Elderly; Who Benefits From Screening After the Age of 60? J Low Genit Tract Dis. Published Online First: 2025. doi: 10.1097/LGT.0000000000000893,

10. Aitken CA, Inturrisi F, Kaljouw S, et al. Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme: A Population-Based Study. Cancer Epidemiol Biomarkers Prev. 2023;32:183–92. doi: 10.1158/1055-9965.EPI-22-0712

11. Heideman DAM, Berkhof J, Verhoef L, et al. Validation of the clinical performance and reproducibility of the NeuMoDx HPV assay self-sample workflow. J Clin Virol. 2024;171. doi: 10.1016/J.JCV.2024.105649

12. Olthof EMG, Aitken CA, Siebers AG, et al. The impact of loss to follow-up in the Dutch organised HPV-based cervical cancer screening programme. Int J Cancer. 2024;154:2132–41. doi: 10.1002/IJC.34902

13. Olthof EMG, Aitken CA, Siebers AG, et al. Resilience of the Dutch HPV-based cervical screening programme during the COVID-19 pandemic. Public Health. 2024;227:42–8. doi: 10.1016/J.PUHE.2023.11.026

14. Verhoef L, Bleeker MCG, Polman N, et al. Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening. Br J Cancer. 2023;129:104–11. doi: 10.1038/S41416-023-02277-Z

15. Castañeda KM, Sidorenkov GA, de Waard J, et al. The effect of extended participation windows on attendance at cervical cancer screening. Prev Med Rep. 2023;32. doi: 10.1016/J.PMEDR.2023.102166

16. Schurink-van ’t Klooster TM, Siebers AG, Hoes J, et al. Early effect of bivalent human papillomavirus vaccination on cytology outcomes in cervical samples among young women in the Netherlands. Cancer Med. 2023;12:11786–94. doi: 10.1002/CAM4.5842

17. Castañeda KM, Sidorenkov G, Mourits MJE, et al. Impact of health-related behavioral factors on participation in a cervical cancer screening program: the lifelines population-based cohort. BMC Public Health. 2023;23. doi: 10.1186/S12889-023-17293-0

18. Kreijne JE, Goetgebuer RL, Erler NS, et al. Cumulative exposure to immunomodulators increases risk of cervical neoplasia in women with inflammatory bowel disease. Aliment Pharmacol Ther. Published Online First: 2023. doi: 10.1111/apt.17555

19. Inturrisi F, Bogaards JA, Siebers AG, et al. Women with a positive high-risk human papillomavirus (HPV) test remain at increased risk of HPV infection and cervical precancer ≥15 years later. Tumour Virus Res. 2022;14. doi: 10.1016/J.TVR.2022.200240

20. Andralojc KM, Elmelik D, Rasing M, et al. Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions. BMC Med. 2022;20. doi: 10.1186/S12916-022-02386-1

21. Wiersma D, Vinke A, Siebers AG, et al. The added value of digital imaging to reflex cytology for triage of high-risk human papillomavirus positive self-sampled material in cervical cancer screening: A prospective cohort study. BJOG. 2023;130. doi: 10.1111/1471-0528.17272

22. Inturrisi F, Rozendaal L, Veldhuijzen NJ, et al. Risk of cervical precancer among HPV-negative women in the Netherlands and its association with previous HPV and cytology results: A follow-up analysis of a randomized screening study. PLoS Med. 2022;19:e1004115. doi: 10.1371/JOURNAL.PMED.1004115

23. Dick S, Vink FJ, Heideman DAM, et al. Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping. Br J Cancer. 2022;126:259–64. doi: 10.1038/S41416-021-01614-4

Ben je als onderzoeker geïnteresseerd in het gebruik van Palga data voor jouw (HPV) onderzoek?
Neem contact met ons op — wij denken graag mee over de mogelijkheden en hoe je die data kunt inzetten voor betekenisvol onderzoek.

Samen kunnen we de impact van HPV verminderen door preventie, screening én evidence-based wetenschap te verbinden.